Collaborators: W. Almers, B. Baird, B. Crane, H. Craighead, W. Lee Kraus, M. Lindau, J. Lis, D. Luo, F. Maxfield, P. McEuen, C. Ober, L. Pollack, M. Wang, W. Webb, G. Whittaker, U. Wiesner

Program Objectives
The Nanoscale Cell Biology Program of the NBTC is aimed at approaching a mechanistic understanding of cellular function with nanoscale precision. To achieve this aim new nano- and microscale tools are developed and applied. Microfabricated devices are also developed to probe cellular function in highly parallel manner for proteomics and drug testing. The approaches include nanoparticles, nanofabricated devices and molecular design. All projects involve interdisciplinary teams with PIs, post-docs and students from many different disciplines supplemented by outside collaborations on the national and international level.

Projects:

1. Tracking Single Molecules and Transport Vesicles in Living Cells Using Fluorescent Nanoparticles - NCB1
   Lindau, Weisner,Webb, Baird
   
   
2. A Scalable n x n Electrochemical Pixel Array with Integrated Electronics for Use as a Highly Parallel Biosensor - NCB2
   Lindau, Ober
   
   
3. Fabrication of Nanoscale Dendrimer-like DNA Structures as Multivalent Templates
   Luo, Baird
   
   
4. Nanotubes as Cellular Biosensors - NCB4
   McEuen, Lindau, Craighead
   
   
5. Development of Novel Applications of Reverse Transfection for High Throughput Cell-based Funtional Screening - NCB6
   Maxfield
   
   
6. Electrochemical Imaging of Exocytosis Using Microfabricated Devices - NCB8
   Lindau, Almers, Craighead, Baird, Ober
   
   
7. Dynamics of Viral Fusion Proteins - NCB9
   Pollack, Whittaker, Crane
   
   
8. Chromatin Structures, Function, and Dynamics: From Mononucleosomes to Polytene Chromosomes - NCB10
   Kraus, Lis, Wang, Webb
   

 

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