Collaborators: W. Almers, B. Baird, P. Chen, B. Crane, S. Daniel, D. Erickson, W. Lee Kraus, M. Lindau, B. Minch, J. Lis, D. Luo, C. Ober, L. Pollack, S. Qian, C. Reinhart-King, C. Schaffer, M. Shuler, M. Wang, W. Webb, G. Whittaker, U. Wiesner
Program Objectives
The Nanoscale Cell Biology Program of the NBTC is aimed at approaching a mechanistic understanding of cellular function with nanoscale precision. To achieve this aim new nano- and microscale tools are developed and applied. Microfabricated devices are also developed to probe cellular function in highly parallel manner for proteomics and drug testing. The approaches include nanoparticles, nanofabricated devices and molecular design. All projects involve interdisciplinary teams with PIs, post-docs and students from many different disciplines supplemented by outside collaborations on the national and international level.
Projects:
- Tracking Single Molecule and Transport Vesicles in Living Cells Using Fluorescent Nanoparticles - NCB1
M. Lindau, U. Weisner, W. Webb and B. Baird
- A Scalable n x n Electrochemical Pixel Array with Integrated Electronics for Use as a Highly Parallel Biosensor - NCB2
M. Lindau, C. Ober and B. Minch
- Fabrication of Nanoscale Dendrimer-like DNA Structures as Multivalent Templates - NCB3
D. Luo and B. Baird
- Electrochemical Imaging of Exocytosis Using Microfabricated Devices - NCB8
M. Lindau, W. Almers, B. Baird and C. Ober
- Dynamics of Viral Fusion Proteins - NCB9
L. Pollack, G. Whittaker, B. Crane and S. Daniel
- Chromatin Structures, Function, and Dynamics: From Mononucleosomes to Polytene Chromosomes - NCB10
W. L. Kraus, J. Lis, M. Wang and W. Webb
- Nanoscale Optofluidic Probing of Cell Migration Mechanics - NCB11
C. Reinhart-King and D. Erickson
- Functional Nano-Molecules: Engineering Ubiquitin Ligases to Target Disease Proteins
- NCB12
S. Qian and P. Chen
- The Role of Biophysical Factors in Cell to Cell Signaling
- NCB13
T. Stokol, M. Shuler and C. Schaffer
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