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Cell-Surface Interactions – Coordinator Barbara Baird

Collaborators: B. Baird, G. Banker, L. Bonassar, A. Boskey, H. Craighead, L. Estroff, C. Fischbach-Teschl, H. Hoch, B. Kirby, W. Shain, A. Stroock, M. Wu

Program Objectives
How cells interact with their environmental substrata is the thrust of this program.  More specifically, the role of surface dimension, chemistry, and topography in regulating cellular behavior are explored in this Program.  A wide range of cell-types, including mammalian cells, higher plant cells, fungal cells, and bacteria have been studied.  The Program utilizes techniques directed at patterning topography and delicate biomolecules that are of greatest biological relevance and documenting their impact on cell growth and polarity, differentiation, and function.  Microcontact printing, lithographic and parylene lift-off patterning of chemical domains, patterning on streptavidin-conjugated acrylamide hydrogels, fabrication of pillared arrays, and incorporation of sensing junctions are some of the techniques used to address the research explorations of this program.  The discoveries made for the cellular processes examined in this program are important in providing insight and perspective for many of the other programs within the NBTC.

Projects:
  1. Cellular Responses to Topographic and Biochemical Clues - CSI3
    Shain, Fischbach-Teschl


  2. Patterned Lipid Bilayers and Zero Mode Waveguides to Investigate Immune Cell Signaling - CSI5
    Baird, Craighead


  3. Colonization and Communication Among Plant-Associated Bacteria in Artificial Xylem Lumina - CSI6
    Hoch, Wu


  4. Divalent Helical Rigid Rods to Engage Receptors and Control Cellular Responses - CSI10
    Ishrat M Khan, Barbara Baird, Harold Craighead and Larry Wang (Clark Atlanta and CREST Member)


  5. Imaging Axonal Growth and Axonal Organelle Transport Using Novel Devices that Integrate Microfluidics and Substrate Micropatterning - CSI11
    Banker, Kirby

  6. 3-D Matrices for Modeling the Bone-Cartilage Interface & Controlling Chondrocyte Activity - CSI12
    Estroff, Bonassar, Boskey, Stroock

  7. Recreating Three-Dimensional Cell Niches with Microfluidic Tumor Cells - CSI13
    Fischbach-Teschl, Stroock, Bonassar


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