NBTC Collaborators: R. Austin, B. Baird, G. Banker, L. Bonassar, A. Boskey, T. Burr, N. Cady, H. Craighead, D. Erickson, L. Estroff, C. Fischbach-Teschl, E. Guignon, H. Hoch, I. Khan, B. Kirby, D. Lawrence, M. López, M. Lynes, F. Maxfield, A. Pilar, M. Shuler, C. Smart, A. Stroock
How cells interact with their environmental substrata is the thrust of this program. More specifically, the role of surface dimension, chemistry, and topography in regulating cellular behavior are explored in this Program. A wide range of cell-types, including mammalian cells, higher plant cells, fungal cells, and bacteria have been studied. The Program utilizes techniques directed at patterning topography and delicate biomolecules that are of greatest biological relevance and documenting their impact on cell growth and polarity, differentiation, and function. Microcontact printing, lithographic and parylene lift-off patterning of chemical domains, patterning on streptavidin-conjugated acrylamide hydrogels, fabrication of pillared arrays, and incorporation of sensing junctions are some of the techniques used to address the research explorations of this program. The discoveries made for the cellular processes examined in this program are important in providing insight and perspective for many of the other programs within the NBTC.