Collaborators: R. Austin, C. Batt, G. Coates, L. Bonassar, E. Cox, D. Lawrence, C. Ober, T. Sato, W. Shain, M. Shuler, M. Spencer, T. Stokol, A. Stroock, M. Wu

Program Objectives
The overall program objectives are to utilize nano- and micro-meter fabricated devices to quantify certain types of cells and their response to the environment in which they are exposed. The cell types under investigation range from bacteria to gastrointestinal endothelial cells.  The parameters being evaluated are physical properties of cells (such as deformability, rigidity, and size), differentiation and growth, viability, release of products, trafficking, and cell communication.  The devices are designed to simulate in vivo conditions allowing high visibility and conservation of reagents and cells.

Projects:

1. Development of a Cell Biosensor - CM1
   Spencer, Lawrence
   
   
2. Nanotechnological Assessment of Drug Toxicity - CM2
   Shuler, Shain
   
   
3. Isolation and Characterization of Immune Cells: Structure and Function - CM5
   Lawrence, Austin, Lynes
   
   
4. Subcellular Molecular Distribution Analysis and Sorting - CM6
   Austin, Lawrence, Cox
   
   
5. Bionanofabrication: In Situ Creation of Nanoscale Polymeric Features - CM9
   Batt, Coates, Ober
   
   
6. Engineering Functional Microvascular Structure in vitro - CM10
   Stroock, Bonassar, Sato, Shuler, Stokol, Wu
   
   

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