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Biomolecular Devices and Analysis - Coordinator Lois Pollack

Collaborators: H. Abruña, J. Appleton, R. Austin, A. Baeumner, B. Baird, T. Clark, G. Coates, H. Craighead, D. Erickson, Q. Hao, K. Jones, D. Lin, M. Lipson, D. Luo, C. Ober, L. Pollack, M. Spencer, S. Tavazoie, L. Walker, W. Webb.

Program Objectives
The overall goal of the “Biomolecular Devices and Analysis” (BDA) program is to use nanofabrication techniques, advanced material and advanced optical systems to develop devices and methods for observing, manipulating, and quantifying the behavior of biomolecules.  More specifically, the program members are developing integrated techniques to interrogate biomolecules suspended in nano- and pico- liter volumes for advancing genomics, proteomics, ecological, and other biological research. The expectation is that by integrating our unique capability to perform molecular separation and analyses at the nano-scale we can develop miniaturized "chip-like" devices for high throughput quantitative analysis of dynamic bioprocesses.  Furthermore, we seek to develop and apply nanostructures and optical confinement systems to study molecular biology at single molecule resolution.

Projects:
  1. Micro & Nanostructures for Molecular Detection, Separation and Analysis - BDA2
    Craighead, Coates, Luo


  2. On-Chip NanoPorous Membranes for Separation and Semipermeable Transport of Biomolecules - BDA3
    Jones, Spencer


  3. Microfabriacted Rapid Fluid Mixers for Protein Dynamics Experiments - BDA11
    Pollack, Webb


  4. Nanoscale Optofluidic Devices for Biomolecular Analysis - BDA13
    Erickson, Baeumner, Lipson


  5. Biosensor Based on Electrochemical/Gravimetric Detection of Intrinsic Antibody Catalysis - BDA14
    Baird, Abruña, Ober, Appleton, Clark


  6. Electronic Detection of Genomic Length DNA in Nanochannels - BDA15
    Austin, Craighead, Tavazoie

  7. Cantilever Array Sensors - BDA16
    Lin, Craighead

  8. A Novel P-gel for Production, Crystallization and Structure Determination of CD31, an Important but Difficult-to-express Protein - BDA17
    Luo, Hao, Craighead

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