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Biomolecular Devices and Analysis - Coordinator Lois Pollack

NBTC Collaborators: H. Abruña, E. Akala, J. Appleton, R. Austin, A. Baeumner, B. Baird, C. Batt, S. Blanchard, T. Clark, H. Craighead, D. Eliezer, D. Erickson, M. Frey, R. Glahn, B. Hyman, S. Jaffrey, K. Jones, W. L. Kraus, D. Lin, M. Lipson, J. Lis, D. Luo, C. Ober, L. Pollack, W. Shain, M. Spencer, P. Soloway, S. Tavazoie, L. Walker, W. Webb, W. Zipfel.

Program Objectives
The overall goal of the “Biomolecular Devices and Analysis” (BDA) program is to use nanofabrication techniques, advanced material and advanced optical systems to develop devices and methods for observing, manipulating, and quantifying the behavior of biomolecules.  More specifically, the program members are developing integrated techniques to interrogate biomolecules suspended in nano- and pico- liter volumes for advancing genomics, proteomics, ecological, and other biological research. The expectation is that by integrating our unique capability to perform molecular separation and analyses at the nano-scale we can develop miniaturized "chip-like" devices for high throughput quantitative analysis of dynamic bioprocesses.  Furthermore, we seek to develop and apply nanostructures and optical confinement systems to study molecular biology at single molecule resolution.

Projects:
(follow links below for project summaries)
  1. Micro & Nanostructures for Molecular Detection, Separation and Analysis - BDA2
    H. Craighead, R. Austin, B. Baird, H. Hoch, D. Lin, J. Lis, P. Soloway and L. Walker


  2. On-Chip NanoPorous Membranes for Separation and Semipermeable Transport of Biomolecules - BDA3
    K. Jones, E. Akala and M. Spencer


  3. Microfabriacted Rapid Fluid Mixers for Protein Dynamics Experiments - BDA11
    L. Pollack and W. Webb


  4. Nanoscale Optofluidic Devices for Biomolecular Analysis - BDA13
    D. Erickson, A. Baeumner and M. Lipson


  5. Biosensor Based on Electrochemical/Gravimetric Detection of Intrinsic Antibody Catalysis - BDA14
    B. Baird, H. Abruña, C. Ober, J. Appleton and T. Clark


  6. Electronic Detection of Genomic Length DNA in Nanochannels - BDA15
    R. Austin, H. Craighead and S. Tavazoie


  7. Cantilever Array Sensors - BDA16
    D. Lin and H. Craighead


  8. A Novel P-gel for Production, Crystallization and Structure Determination of CD31, an Important but Difficult-to-express Protein - BDA17
    D. Luo and H. Craighead

  9. Application of Micro- and Nanoscale Fluidic Devices for Studying Early Aggregation Properties of α-Synuclein and β-Amyloid Peptides - BDA18
    W. Zipfel, W. Webb, D. Eliezer and B. Hyman

  10. Creation of Functional Electrospun Bionanofibers in Microfluidic Channels - BDA19
    A. Baeumner and M. Frey

  11. Development of a multiplex device for large-scale selection of RNA aptamers - BDA20
    J. Lis and H. Craighead

  12. Single Molecule Analysis of Epigenetic States - BDA21
    P. Soloway and H. Craighead

  13. Nanotechnological Assessment of Drug Toxicity - BDA22
    M. Shuler, W. Shain, R. Glahn and W. L. Kraus

  14. SERS Enhanced Ligase Detection Reaction Chip for the Molecular Diagnosis of Cancer - BDA23
    D. Erickson and C. Batt

  15. A Novel Aptamer-Based Approach for Label-Free Protein-Sensing Microarrays - BDA24
    S. Jaffrey and S. Blanchard

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