This technology mimics the vascular system of the human body, carrying oxygen, sugar, proteins and growth factors to cells contained within a scaffold. The system is composed of microchannels embedded in a water-based gel, holding millions of living cells which can be formed to fit desired shapes.
“Whereas most microfabrication is done into silicon or glass, here we are microfabricating into a living tissue to put in these capillaries,” said Prof. Abraham Stroock, chemical and bio-molecular engineering, a co-author of the study, “and we can then use these capillaries as the microvascular system to keep the tissue alive and direct the tissue towards the desired structure and biological function.”
The research is a key development in tissue engineering, as past technology could not adequately circulate vital fluids among cells within a scaffold.
“One of the limitations of growing tissue outside the body is that they’re not hooked up to a vascular system that nourishes them in the body,” said Prof. Lawrence Bonassar, biomedical engineering, another co-author of the study. “We can create an artificial vascular system to keep these tissues alive for longer and potentially make larger tissues than can be made with other existing technology.”
This research has implications for patients in need of tissue repair or replacement.
“We’re trying to grow a piece of living tissue that one day could be implanted back into a patient to repair a defect or an injured sight, or even replace a defective organ or tissue,” Stroock said.
|Ithaca-Weill collaborations spur videoconferencing upgrades|
|October 12, 2007 - Students in Biophysical Methods (A&EP 570) are taught by Manfred Lindau, professor of applied and engineering physics, and Fred Maxfield, professor and chair of the Department of Biochemistry at Weill Cornell Medical College in New York City. Maxfield doesn't commute. He lectures from New York City, appearing larger than life on a screen in 162 Hollister Hall.
In this state-of-the-art classroom, anyone who wants to ask a question can push a small button to turn on a microphone embedded in the desk; a camera mounted on the front wall zooms in on the questioner, allowing Maxfield some visual feedback. The rest of the time he sees the whole classroom.
"The visual clue is important to the presenter," says Graham Kerslick, associate director of the Cornell Nanobiotechnology Center. "If people are looking slightly baffled, you know it's just a little over their heads."
The Nanobiotechnology Center holds weekly seminars that also include Weill-Cornell faculty as virtual visitors, and a growing number of other research groups and classes are exploiting the ability to meet Weill faculty and students face-to-face, so to speak. Videoconferencing has become easier since Cornell established a 10 gigabit per second fiber optic pipeline between Ithaca and New York City, and Cornell Information Technologies' (CIT) Project Ezra has strung new fiber connections to classrooms.
Side-to-side shaking of nanoresonators throws off impurities, researchers find
|October 12, 2007 - Tiny vibrating silicon resonators are of intense interest in nanotechnology circles for their potential ability to detect bacteria, viruses, DNA and other biological molecules.
Cornell researchers have demonstrated a new way to make these resonators vibrate "in the plane" -- that is, side to side -- and have shown that this can serve a vital function: shaking off extraneous stuff that isn't supposed to be detected.
The research is reported in the July 14 online version of the journal Nano Letters and in the August print edition.
The typical resonator is a cantilever -- a narrow strip of silicon a few millionths of a meter long that can be made to vibrate up and down like a diving board just after someone jumps off. In research aimed at building the much-sought "lab on a chip," Professor Harold Craighead's group at Cornell and other researchers have shown that by binding antibodies to such resonators they can cause pathogens to attach to them. At the nanoscale, just adding the mass of one bacterium, virus or large molecule is enough to change the resonant frequency of vibration of the cantilever by a measurable amount, thereby signaling the presence of the pathogen. Go to the full Chronicle Article
|CU researchers shed light on light-emitting nanodevice|
|Oct. 3, 2007 - An interdisciplinary team of Cornell nanotechnology researchers has unraveled some of the fundamental physics of a material that holds promise for light-emitting, flexible semiconductors.
The discovery, which involved years of perfecting a technique for building a specific type of light-emitting device, is reported in the Sept. 30 online publication of the journal Nature Materials.
The interdisciplinary team had long studied the molecular semiconductor ruthenium tris-bipyridine. For many reasons, including its ability to allow electrons and holes (spaces where electrons were before they moved) to pass through it easily, the material has the potential to be used for flexible light-emitting devices. Sensing, microscopy and flat-panel displays are among its possible applications.
The researchers set out to understand the fundamental physics of the material -- that is, what happens when it encounters an electric field, both at the interfaces and inside the film. By fabricating a device out of the ruthenium metal complex that was spin-coated onto an insulating substrate with pre-patterned gold electrodes, the scientists were able to use electron force microscopy to measure directly the electric field of the device.
|Go to the full Chronicle article|
|Researchers mimic vascular system to nourish engineered tissue for transplants|
|Oct. 5, 2007 - One day soon, laboratories may grow synthetically engineered tissues such as muscle or cartilage needed for transplants. In a major step forward, Cornell engineers describe in the journal Nature Materials a microvascular system they have developed that can nourish growing tissues.|
The researchers have engineered tiny channels within a water-based gel that mimic a vascular system at the cellular scale and can supply oxygen, essential nutrients and growth factors to feed individual cells. The so-called gel scaffold can hold tens of millions of living cells per milliliter in a 3-D arrangement, such as in the shape of a knee meniscus, to create a template for tissue to form.
In theory, the system could accommodate many kinds of tissue.
"A significant impediment to building engineered tissues is that you can't feed the core," said Abraham Stroock, Cornell assistant professor of chemical and biomolecular engineering and one of the paper's senior authors. "Simply embedding this mimic of a microvascular system allows you to maintain the core of the tissue during culture." Gel scaffolds, he said, "are the culture flasks of the future."
|Cornell's Nanobiotechnology Center to lead NSF-funded research in flexible electronics and biosensors|
September 11, 2007 - Growing interest in using flexible electronics for next-generation biomedical devices has prompted the creation of a new graduate student research program at Cornell, funded by the National Science Foundation (NSF).
Cornell's Nanobiotechnology Center (NBTC) has received $3.2 million over five years from NSF's Integrative Graduate Education and Research Traineeship (IGERT) program. Recruited IGERT fellows will work in teams to design and test biodevices -- from biologically compliant neural implants to wireless drug delivery -- using flexible electronics.
Called the FlexEBio research grant, the program will focus on: biosensors; the material-biology interface; and flexible implantable electronics for medical monitoring, diagnostics and therapeutics.
The broad research area of flexible electronics has been developing over the past decade, said Christopher Ober, the F.N. Bard Professor of Materials Engineering and principal investigator. Such efforts have to date produced flexible displays and flat-panel lighting, as well as circuitry printed onto flat, plastic substrates -- using methods similar to how an inkjet printer prints on paper. Go the full Chronicle article
|Cornell University professor named top innovator|
|August 16, 2007 - Six years ago, the capillary systems of a giant California redwood tree inspired Abraham Stroock to engineer life. How could an organism hundreds of feet tall pump water to every leaf?
Now he's building capillary systems of his own.
MIT's Technology Review magazine recognized him on Wednesday for his efforts. The publication named Stroock, an assistant professor of chemistry and biomechanical engineering at Cornell University, to the magazine's annual list of the 35 top young innovators under 35, a group of young men and women who embody innovation in business, technology and the arts.
Stroock, 34, was selected for his work with microfluidic biomaterials, the science of creating synthetic vascular systems that mimic the real life chemical transport systems of organisms. Using hydrogels that are similar to human tissue, he and a research team at Cornell have developed materials that “capture aspects of what biological systems do” to move fluids throughout a tissue-like material. Go to the full Ithaca Journal article
|Cornell University Assistant Professor Abraham Stroock, center, has been named one of the 35 top young innovators nationwide by MIT's Technology Review magazine. Stroock and his graduate students, Tobias Wheeler, left and Nakwon Choi use optical microscopes to study micro hydrofluidic systems.|
|Cornell researchers develop virus-size 'nanolamps' that could aid use of flexible electronic devices as sensors|
February 12, 2007 - To help light up the nanoworld, a Cornell interdisciplinary team of researchers has produced microscopic "nanolamps" -- light-emitting nanofibers about the size of a virus or the tiniest of bacteria.
In a collaboration of experts in organic materials and nanofabrication, researchers have created one of the smallest organic light-emitting devices to date, made up of synthetic fibers just 200 nanometers wide (1 nanometer is one-billionth of a meter). The potential applications are in flexible electronic products, which are being made increasingly smaller. Go the full Cornell Chronicle article here
|Harold Craighead Elected to National Academy of Engineering|
February 12, 2007 - Two members of Cornell's engineering faculty -- Harold Craighead, the Charles W. Lake Jr. Professor of Engineering, and Éva Tardos, professor and chair of the Department of Computer Science -- are among 64 new members and nine foreign associates elected to the National Academy of Engineering (NAE).
Election to the academy is among the highest professional distinctions accorded to engineering faculty members. Go the full Cornell Chronicle article here
|Five Cornell faculty members honored as AAAS Fellows|
January 23, 2007 - Five members of the Cornell faculty have been named fellows of the American Association for the Advancement of Science (AAAS), the world's largest general scientific society and publisher of the journal Science. The researchers will be recognized at the annual AAAS meeting, held this year in San Francisco on Feb. 17.
Those being honored are Hector Abruña, the E.M. Chamot Professor of Chemistry and Chemical Biology and department chair; Barbara Baird, professor of chemistry and chemical biology; Geoffrey William Coates, professor of chemistry and chemical biology; Michael Shuler, the S.B. Eckert Professor of Chemical and Biomolecular Engineering and the J. and M. McCormick Chair of Biomedical Engineering; and Mariana Wolfner, professor of molecular biology and genetics. Go the full Cornell Chronicle article here
|Cornell-developed exhibit at Disney's Epcot offers youngsters a window into too-small-to-see nano world|
November 17, 2006 - A world that is too small to see is going to seem a bit bigger when visitors get a chance to interact with, build, play and watch molecules in an interactive exhibit, "Too Small to See," which opens Nov. 18 at Epcot's Innoventions at Walt Disney World, Lake Buena Vista, Fla.
And in mid-May through fall 2007, the arcade-like, 5,000-square-foot museum exhibition, developed by a team led by Carl Batt, the Liberty Hyde Bailey Professor of Food Science at Cornell, will be at Ithaca's Sciencenter before traveling throughout the United States.
The exhibit, aimed at 8- to 13-year-olds, helps visitors view the world at the atomic scale and to better understand just how small a nanometer -- one billionth of a meter -- is (it is to a meter what 2.5 centimeters are to about two-thirds of the way around the Earth.) Go to the Chronicle article
|It's a really small world after all: Sciencenter puts big focus on little things|
October 11, 2006 - A popular exhibition that introduces children to the world of nanotechnology returned Monday to Ithaca.
The exhibition, “It's a Nano World,” will be at the Sciencenter through December. The exhibition is designed to teach children ages five years old to eight years old about Nanobiotechnology.
Nanobiotechnology is the study and creation of biological technology on an extremely small scale.
“It's using these very tiny tools to learn about living things, that's our main message throughout the exhibition,” said Catherine McCarthy, grant projects director for Sciencenter. McCarthy was also the exhibition's project manager. Go to Ithaca Journal article
|Cornell's Nanobiotechnology Center becomes model for teaching in Kentucky|
Jul 19, 2006 - A researcher from Kentucky State University has chosen Cornell's National Science Foundation (NSF)-funded Nanobiotechnology Center (NBTC) to fulfill a faculty-training grant that will allow him to create a nanobiotechnology course at his home institution.
Narayanan Rajendran, assistant professor of molecular microbiology and biotechnology at Kentucky State University and a visiting assistant professor at Cornell, was one of five faculty members nationwide to receive an award, funded by the NSF through the Quality Education for Minorities (QEM) Network, a nonprofit organization based in Washington, D.C. The grant supports minority faculty members to train at one of 13 science and technology centers around the country and then to return to their home institutions and implement new programs and courses. Go to Chronicle Article.
|Cornell Museum Exhibits Allow Children to Enter World of the Very, Very Small|
Feb 18, 2006 - ST. LOUIS, Mo. - Science learning isn't all in books. Sometimes you can hold it in your hand, walk through it, sit inside it, play with it. Those approaches are especially effective with children and can make abstract concepts easier to understand. Take nanotechnology for example. Over the last three years, elementary school children all over the United States have been learning about incomprehensibly tiny things by walking through and playing with very large and colorful things in a traveling science museum exhibition created by Cornell University's National Science Foundation (NSF)-funded Nanobiotechnology Center (NBTC) in partnership with the Sciencecenter, Ithaca's hands-on science museum, and Painted Universe, a local design firm. Go to Chronicle article.
|Cornell Scientists Build 'Nano-Keys' to Bind Cell Receptors and Trigger Allergic Reactions|
Feb 16, 2006 - ST. LOUIS, Mo. - Cornell University researchers have fabricated a set of 'nano-keys' on the same scale as molecules to interact with receptors on cell membranes and trigger larger-scale responses within cells, such as the release of histamines in an allergic response. How cell membranes control cellular function has long been studied but with few results. However, nanotechnology now gives researchers new tools to better understand the role of cell membranes in activitating responses within cells. Go to Chronicle article.
"It's a Smaller World"
Sep 26, 2005 - Starting Oct.1, kids and their families who visit the Cranbrook Institute of Science will get a taste of an even smaller world. The "It's a Nano World" exhibit runs through Dec. 31, and promises children and adults alike an introduction to nanobiotechnology. See also http://www.michigansmalltech.com/
"Key cellular enzyme plays key role in gene regulation, CU team finds"
Feb 10, 2005 - A cellular enzyme known to biologists for years just got a startling makeover. The discovery by a researcher with dual appointments at Cornell and Weill Cornell Medical College in New York City that poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in gene transcription could open doors to new therapies for cancer and neurological disease. There are even hints at connections between the foods we eat and gene expression within our cells. Go to Chronicle article.
"Slime and science rule after school"
Jan 13, 2005 - Cornell University and Onondaga Nation School partner in a science education project. Twice a month after school, pupils in the Science Club at the Onondaga Nation School learn new experiments from Cornell University faculty members.
Go to Post-Standard article
"Main Street Science"
Nov 18, 2004 - A new learning "collaboratorim that advances the science literacy of elementary school students and the general public."
Jul 2 , 2004 - While "Its a NanoWorld" crisscrosses the country, the creative team behind it has gotten the green light for a sequel.
"Cornell researchers move beyond 'nano' to 'atto' to build a scale sensitive enough to weigh a virus "
Apr 2 , 2004 - Cornell University researchers already have been able to detect the mass of a single cell using submicroscopic devices. Now they're zeroing in on viruses. And the scale of their work is becoming so indescribably small that they have moved beyond the prefixes "nano" "pico" and "femto" to "atto." And just in sight is "zepto."
Go to News Release.
" Main Street Science - Teaching community-based science"
Jan 9 , 2004 - Over the past four years the Nanobiotechnology Center, a National Science Foundation supported effort with Cornell University as the lead institution, has been actively engaged in the greater Ithaca community. Our mission is to foster a life-long interest in science and technology by teaching people of all ages about the nano world.
Go to Ithaca Journal article.
Jan 9 , 2004 - The world too small to see is revealed in a traveling science museum exhibition, "It's a Nano World," which is on view at Innoventions at Epcot in Lake Buena Vista, Fla., through March 1. It is the first exhibit at Innoventions to highlight nanotechnology.
Go to Cornell Chronicle article.
"Symposium offers small solutions to big medical challenges"
Jul 10, 2003 - Scientists at Cornell's Nanobiotechnology Center (NBTC) continue to show that little things can have big impacts. At the NBTC's annual research symposium June 27, Cornell scientists and their collaborators met to discuss new developments in the fledgling field of nanobiotechnology. Speakers from universities and laboratories across the country, as well as Dublin City University and the University of Glasgow, met in the Biotechnology Building to share ideas and give updates on the progress of their research. The talks were followed by a poster session in Clark Hall, where the work of 47 NBTC projects was on display.
Go to Chronicle article.
"CU research finding opens applications in medical imaging"
June 26, 2003 - Twelve years after its patent was granted, the technique called multiphoton microscopy appears ready to move from the realm of biological research to medical imaging. In a series of three papers published this spring in the scientific literature, Watt W. Webb, Cornell's Eckert Professor of Engineering and co-inventor, with Winifried Denk, of multiphoton microscopy, displayed images of living tissue with details that rivaled -- and in some cases surpassed -- those from more traditional imaging processes. Go to Chronicle article.
"Undergraduate Creates Nanofilter for Biomedical Lab-on-a-Chip"
April 16, 2003 - ARLINGTON, Va. - In the miniaturized world of the "lab-on-a-chip," still a few years away, a pinprick will funnel a tiny droplet of blood into a microscopic maze of fluid circuits, sensors and filters-all housed on a device no bigger than a credit card. With these devices, doctors will get the results from many basic screenings immediately, instead of having to wait for blood samples to be shipped to a lab for analysis. Go to NSF web site story.
"CU chemist finds way to make biodegradable plastic that mimics bacteria "
April 3, 2003 - Finding an economical way to make a polyester commonly found in many types of bacteria into a plastic with uses ranging from packaging to biomedical devices is a long-held scientific goal. Such a polymer would be a "green" plastic, in that it would be biodegradable. Go to Chronicle article.
April 3, 2003 - The fouling of ships' hulls, whether by barnacles and seaweed or by slime-creating bacteria, is a major problem for shipping worldwide, and particularly for navies. It has been estimated, for example, that fouling of hulls can create such turbulence as a ship moves through the water that fuel consumption is increased by as much as 30 percent. Go to Chronicle article.
"High School Students create Neat Stuff at the NBTC"
"Cornell links teachers, science"
August 14 , 2002 - ITHACA -- Having viewed a human hair, a red blood cell, and an E. coli bacterium through a microscope, South Hill teachers Carrie LaZarre and Joanne McBride were drawing pictures of them to scale Tuesday morning.
Go to Ithaca Journal article
"CU protein researcher is named among 100 top young innovators"
May 23, 2002 - Technology Review, a magazine published by the Massachusetts Institute of Technology, has named Kelvin H. Lee, assistant professor in the School of Chemical and Biomolecular Engineering at Cornell, among the "World's Top 100 Young Innovators in Technology and Business."
Go to Chronicle article
"Cornell researchers collaborate on a major advance in microfabrication"
May 16, 2002 - University of Arizona (UA) scientists and their colleagues at Cornell have become the first researchers to engineer molecules that efficiently absorb two particles of light, or photons, at the same time and trigger acid production at any point in three dimensions in the materials. Go to Chronicle article
(see also our publications web page for abstract)
"Lansing students, with CU advice, will have experiment sent to Mars"
"CU researchers turn "plumber's nightmare" into new, flexible ceramics"
Mar 21, 2002 - Using nanoscale chemistry, researchers at Cornell have developed a new class of hybrid materials that they describe as flexible ceramics. The new materials appear to have wide applications, from microelectronics to separating macromolecules, such as proteins. Go to Chronicle article
"Science fun that's on target"
Nov 9, 2001 - Nanobiotechnology Center's science club for girls meets in the Biotechnology Building at Cornell.Go to article
"CU scientists work on novel biomolecular materials based on silkworm silk"
"Barbara Baird named director of university's Nanobiotechnology Center"
June 28, 2001 - Barbara Baird, a leading researcher in the allergic immune response system at the molecular level, has been named director of Cornell's Nanobiotechnology Center (NBTC). She succeeds Harold Craighead, who has been named interim dean of the Cornell College of Engineering. Go to Article
"Scientists, students see nanobiotechnology advances at NBTC meeting"
June 28, 2001 - Less than two years after its founding, participants in the Cornell-based Nanobiotechnology Center (NBTC) reported significant progress in efforts to probe biology in the "nano" scale and make devices that interface with living systems. Some nanobotechnologists speaking at a June 22 meeting at the university's Weill Cornell Medical College in New York City also sought to distinguish realistic potential from science-fiction hype in a field whose mantra is smaller, faster and more of everything. Go to Article
"New process for producing near-atomic scale silicon structures - nanobumps - developed by Cornell researchers"
April 4, 2001 - An engineer and a chemist, working together on a corporately funded research project at Cornell University, are reporting a fundamentally new way to fabricate nanoscale structures on silicon that promises the development of devices... Go to Article
"Its a (Very) Small World"
March 1, 2001 - Dr. Darlene Solomon, Director of Agilent Labs' Life Science Technologies Laboratory, has been elected to the Advisory Board of the Nanobiotechnology Center (NBTC)--a new $20 million facility funded by the U.S. National Science Foundation...
Go to Article
"Craighead reports on use of nanotechnology to count biological molecules"
February 22, 2001 - Up to now, most biologists have studied the molecules of life in test tubes, watching how large numbers of them behave. But now Cornell researchers are using nanotechnology to build microscopic silicon devices ...Go to Article
February 2001 - Nanotechnology is shaping up to be the science of the twenty-first century. Most people can agree on that much from President Clinton to cutting-edge researchers to Luddite activists. It's also a buzzword that can unlock research dollars and sell science fiction books...Go to Article
"Pataki targets $700,000 to Cornell"
January 17, 2001 - In Governor Pataki's budget proposal, Cornell University is included explicitly and will receive $700,000 in funds as part of a new $1 billion plan to connect university-based research with business creation and job development ...Go to Article
•Cornell Chronicle, 9/14/00, "Harold Craighead: 'The idea is catching fire all over the world'"
•Cornell Chronicle, 8/31/00, "Viewing nanobiotechnology"
• Cornell Chronicle, 6/15/00, "Splitting hairs"
•Cornell Chronicle, 5/18/00, "Nano-researchers create device that speeds separation of DNA fragments"
•Cornell Chronicle, 5/4/00, "Nanobiotech workshop brings engineers and biologists face-to-face
•Cornell Chronicle, 4/27/00, "CU's new Keck program in nanobiotech supports graduate scientists"
•Cornell Chronicle, 4/6/00, "Former teacher heads center's outreach program"
• Cornell Chronicle, 12/22/99, "Sen. Charles Schumer hears from Cornell researchers about need for federal aid to bring biotechnology to market"
•Cornell Chronicle, 6/30/99, "National Science Foundation funding launches Nanobiotechnology Center at Cornell"
|This material is based upon work supported in part by the STC Program of the National Science Foundation under Agreement No. ECS-9876771. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.|